Predictors of Left Ventricular Deterioration in Individuals with or without Type 2 Diabetes - The Hoorn Study (WC2005-011)

Background

Starting date: 01/12/2006 Patients with type 2 diabetes (DM2) have an increased risk of left ventricular (LV) hypertrophy and symptomatic and asymptomatic LV dysfunction. In cross-sectional data from the Hoorn Study, the increased LV mass in DM2 could not be explained by arterial stiffness or impaired flow mediated vasodilation, or traditional risk factors, such as hypertension, obesity, etc. In contrast to increased LV mass, of which less than 10% could be attributed to insulin and glucose levels, over 30% of the elevated prevalence of systolic and diastolic LV dysfunction was attributable to high levels of insulin and glucose.
This study will be the first population based prospective study with repeated echocardiographic examinations of LV structure and function. We hypothesize that progression of LV deterioration will be related to insulin resistance, metabolic syndrome, arterial stiffness, endothelial dysfunction, micro-vascular angiopathie, and low grade inflammation.